As a supplement, manufacturers extract Alpha GPC from Soy Lecithin. Choline, while naturally present in the body, is a water-soluble compound extracted from purified soy lecithin for commercial resale. Change your life with natural nutrition backed by science. It is also a parasympathomimetic acetylcholine precursor [1] which has been investigated for its potential for the treatment of Alzheimer's disease [2] and other dementias. I would definitely recommend this product to anyone looking for a cognitive boost. - daydreamr8. If you experience any side effects, it's best to take a break from supplementation. (Harvard Medical School and McClean Hospital - 7), 3. Let us know about your experience with Alpha GPC in the comments below! Acetylcholine is a neurotransmitter involved in memory formation and learning and is also necessary for muscle contraction. Alpha GPC benefits the brain in many ways. Once a supplement like Alpha GPC is absorbed, it is metabolized into both glycerophosphate and choline (the precursor to acetylcholine). You can take this amount all at once or split your servings throughout the day or as needed. 2. Choline plays another critical role in connecting our brain-cells together. He takes joy in learning and superseding current peptide developments toward neurological diseases. This is significant to focus because dopamine is "motivation" at a chemical level. A-GPC use also increased physical force, with peak bench press force being 14 percent greater compared to placebo. Increasing your Alpha GPC dosage beyond this point does not necessarily translate to better performance or increased HGH production. [9], A 2021 cohort study of more than 12 million participants (at least 50 years old), including 108,877 alpha-GPC users, reported that alpha-GPC use for at least 12 months was associated with an increased risk of stroke over 10 years. In one study, healthy men aged 18-39 saw immediate memory-recall gains. JAMA Netw Open 2021;4(11):e2136008. Alpha-GPC is legal in the United States and most other countries. These products are not intended to diagnose, treat, cure or prevent any disease or health condition. The information found on WholisticResearch is intended for informational and educational purposes only. The finer details and scientific reasoning behind this: 1. Alternatively, you can purchase alpha GPC on Amazon. This means that 1000 mg of Alpha-GPC provides about 400 mg of choline. What Nootropics Are Similar To Alpha-GPC? Users have occasionally experienced headaches, fatigue, nervousness, nausea, diarrhea, and gastrointestinal distress. They typically only surface when going far beyond the recommended dose. There are a lot of products out there that are cut with other compounds, and you want to ensure you're getting what you're paying for. OTHER NAME(S): Alfa-GPC, Alpha Glycerol Phosphoryl Choline, Alpha, Alpha-GPC (L-alpha-glycerylphosphorylcholine) is a chemical made in the body from choline. Alpha GPC can be effective for some users at a dose of 200 to 250 mg. As Alpha-GPC is one of the most potent sources of choline available in a supplement (approximately 40% potency), you dont need a big dose as you might with other nootropics. 1000mg of Alpha GPC was studied to significantly increase growth hormone after 65 minutes of ingestion. Alpha GPCs ability to stimulate the production of human growth hormone has not been extensively studied. View abstract. Alpha GPC is a precursor to acetylcholine. Let's take a closer look at how Alpha-GPC can benefit your cognitive function and overall brain health. Theres a good chance that if youre reading this Alpha GPC review, you already have some basic knowledge on choline. 2005 - 2023 WebMD LLC, an Internet Brands company. Alpha-GPC increases a chemical in the brain called acetylcholine. Alpha GPC is a natural cholinergic that has cognitive enhancing and neuroprotective properties. Our mission is to provide you with everything you need to know to get started with nootropics including guides for beginners, stack ideas, and detailed supplement profiles. In general, this Alpha GPC dose is both recommended and well-tolerated. Alpha-GPC has been shown to improve cognitive function in healthy adults, and it's also used to treat Alzheimer's disease and dementia. As you can see, people are generally very happy with the results they've seen from taking Alpha-GPC. View abstract. In this ultimate guide to Alpha GPC, you're going to see many studies highlighting this compounds neurodevelopment and memory benefits. Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial., Herholz, Karl. Your age and personal health also play a role. Here are some interesting results that researchers have seen regarding memory-gain: The University of Milan saw Alpha GPC to benefit short-term and long-term memory. After that, you can consider cycling off of it for a week or two to avoid any tolerance build-up. [3][1] Alpha-GPC may also improve the effectiveness of acetylcholinesterase inhibitors (i.e., drugs that increase acetylcholine availability by slowing down its breakdown), which are used for treating Alzheimers disease. (Trabucchi M. - 9), 5. When we form long-term memories, we use proteins to "solidify" the link in our neural network. Other studies have suggested that Alpha GPC can improve memory formation as well as learning ability. Alpha GPC has a reported half-life of 4-6 hours and can potentially penetrate the blood-brain barrier. I've noticed an increase in my mental clarity, and my memory has improved. Half life: 4-6 hours (reported BBB: Penetrant (in animal models): 2 ongoing in ongoing in diabetic elderly, 16 completed studies Observational studies: 0 What is it? [11] Our previous article on the types of choline supplements makes the comparison in detail. 2012 - 2023 BRAINTROPIC Braintropic does not provide medical advice, diagnosis, or treatment. View abstract. Neuroscientists call this long-term potentiation. Acetylcholine is dubbed the learning neurotransmitter and is responsible for just that memory and learning. Alpha-GPC is a compound known for improving mental performance and endurance by increasing attention span ( 2 ). 7. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. First, make sure you're buying from a reputable source. We wont dive into detail on the other two choline sources. (The University of Barcelona - 8), Researchers observed that Alpha GPC increases the activation of striatal dopaminergic output. Alpha-GPC Alpha-glycerophosphocholine (alpha-GPC or -GPC) is a cholinergic compound that is used for cognitive-enhancement, and to increase power output in athletes. Understand how much Choline Alpha GPC gives you: Alpha GPC is 40% Choline by weight, which means that each 250mg Alpha GPC capsule would give you 100mg of Choline, 1 gram of Alpha GPC powder would give you 400mg of Choline and 1 gram of Alpha GPC 50% powder would give you 200mg of Choline. Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. Calculate your current Choline intake: Roughly work out your daily Choline intake from your diet. A clinical trial was carried out on 120 patients with mild to moderate vascular dementia. Choline has been widely studied to be integral to our cognition and overall brain development. This stack is designed for overall cognitive enhancement. Choline improves executive function and reaction times. As a nootropic, Alpha GPC easily crosses the blood-brain barrier. Ann N Y Acad Sci 1994;717:253-69. Alpha GPC is an excellent choline source for use in stacks with other nootropics, particularly the racetams. All the best nootropic stacks contain a reliable choline source to aid in your brains production of acetylcholine. However, choline concentrations high enough for nootropic benefits such as improving focus require supplementation. It appears to also support cellular membranes, and may help prevent cognitive decline. The dosing recommendations below refer to the total amount of Alpha GPC ingested not the 40% choline output. For most adults, the range of acceptable dosage is fairly wide; a cumulative daily dosage of 3001200 mg taken in one to three doses has been documented as safe and effective. CDP-Choline is only about 18% choline by weight, while Choline Bitartrate is about 40% choline. However, levels of Alpha-GPC tend to decline with age, which is why many people take it as a supplement. In our review of Alpha GPC, weve covered many of its cognitive enhancement and health benefits. (Boston University - 4). For nootropic users seeking cognitive enhancement and neuroprotection, keep your dose in the 300-600mg range. Age-related declines in exploratory behavior and markers of hippocampal plasticity are attenuated by prenatal choline supplementation in rats. [10] Moreover, a 2021 mouse study found that alpha-GPC supplementation promoted atherosclerosis. We currently have no information for ALPHA-GPC overview. Finding your optimal dosage: Some people have seen better results from exceeding the official recommended dose. A water-soluble supplement, alpha GPC is both fast-acting and highly bioavailable when taken orally. The study found that alpha GPC users were at a higher risk for a stroke than non-users. This allows us to provide free, fact-based information without ads. Alpha GPC contains more Choline than CDP Choline: Alpha GPC is 40% Choline by weight, whereas Citicoline is 18.5% Choline by weight. This is our main nerve messenger, according to Dr. Zeisel. Formula of science-backed, natural ingredients. Clin Ther 2003;25:178-93. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Alpha-GPC works by increasing levels of acetylcholine (ACh) in the brain. Alpha-GPC is thought to help prevent age-related decline in cognitive function by increasing levels of acetylcholine in the brain by acting as a pro-cholinergic nootropic agent (4). Alpha GPC is generally well tolerated when taken at recommended dosages. You're now set up to receive our newsletter that will keep you up to date with the latest and greatest in nootropics! In this section, we will outline some of the major studies as they related to the two main areas of effectiveness of Alpha GPC memory & cognition and physical performance. The side effects of Alpha GPC listed below are rare. If you happen to experience any of these side effects, youve gone too far in your dose. Alpha GPC contains twice the Choline content than CDP Choline. View abstract. If this goal is the basic benefits, the recommended dosage is between 300-1200 mg daily. There are a number of rodent studies that support this effect, but it has yet to be shown in otherwise healthy humans. Low levels of phosphatidylcholine are associated with neurological disorders, including Alzheimers disease,[16] dementia,[17] and schizophrenia.[18], The recommended dosage for alpha GPC, based on studies on its use in alleviating cognitive decline, is 1200 mg daily, divided into three doses of 400 mg.[19], This is also the dosing recommendation for Glilitin, the Russian prescription form of alpha GPC.[20]. L-Theanine: Review of Nootropic Benefits, Uses, & Side Effects, L-Tyrosine: Review of Nootropic Benefits, Uses, & Side Effects, Ginkgo Biloba: Review of Nootropic Benefits, Uses, & Side Effects, French Maritime Pine Bark Extract: Review of Nootropic Benefits, Uses, & Side, Rhodiola Rosea: Review of Nootropic Benefits, & Uses, Citicoline (Cognizin): Review of Nootropic Benefits & Uses, All Articles About Vitamins & Supplements, Best Legal Over the Counter Adderall Alternatives, How to Improve Cognitive Ability & Skills, Perfect for people who want to improve their cognitive function, Can help people with Alzheimer's disease and dementia, Not the ideal nootropic for people taking anticholinergics such as Scopolamine (Devil's Breath), Treating Alzheimer's disease and dementia, Improved memory and cognitive performance in elderly adults, Tamura, Yasuhisa et al. 5. 5. Studies show that its also a neuroprotectant that helps maintain the biochemical balance of the brain. If you happen to experience any of these side effects, you've gone too far in your dose. Though there are a few dietary sources of alpha GPC (most notably, dairy products, organ meats, and wheat germ), studies show that it only becomes pharmacologically active at high concentrations that are only attainable via supplementation. This could be in the morning, before an important meeting, before an exam, or any other time when you need to be sharp. Decreased lysophosphatidylcholine/phosphatidylcholine ratio in cerebrospinal fluid in Alzheimers disease. Then, space your doses by 8-12 hours. The cholinergic compound has demonstrated the potential ability to reverse all AD symptoms. Alpha-GPC, also known as choline alfoscerate and L-Alpha glycerylphosphorylcholine, is a natural choline compound found in the brain. When ingested, alpha-GPC is metabolized into choline and glycerol-1-phosphate. It can also provide users with the mental clarity that can help them get meaningful work completed. Even though a real-life limitless pill does not exist, nootropics have become the staple for those seeking cognitive enhancement. Wang Z, Hazen J, Jia X, et al. While Alpha-GPC is generally safe, it can cause some side effects like headaches. Alpha-glycerophosphocholine (alpha-GPC or -GPC) is a cholinergic compound that is used for cognitive-enhancement, and to increase power output in athletes. Simply reduce Alpha GPC intake back to an acceptable amount for your body. Alpha GPC is 40% Choline by weight. This increase in power output is largely due to the ability of Alpha GPC to increase plasma growth hormone secretion. Each molecule of alpha GPC is made up of about 40% choline, which it delivers directly to the brain.[12], Alpha GPCs ability to cross the blood-brain border makes it a particularly efficient cholinergic, surpassing other cholinergics and even choline itself at increasing circulating levels of choline in the central nervous system.[13]. Alpha GPC happens to be a more bioavailable form of choline that can easily cross the blood-brain barrier. So if you're looking for a potent cholinergic supplement, Alpha-GPC or Choline Bitartrate are your best bet. In other words, its not going to raise your neural (brain) Uridine levels that much. A pilot study indicated that a 600 mg dose of alpha GPC, taken 90 minutes before bench pressing, increased power by 14%.[10], Another small study involving eight healthy young men under 25 showed that a single dose of alpha GPC increased growth hormone secretion and hepatic fat oxidation, both of which are associated with increased energy and reduced recovery time.[11]. The half-life of . Most people tend to get around 200mg of Choline per day from their diet. For performance-enhancing benefits through acute supplementation: 600 mg of alpha-GPC taken 30-90 minutes before exercise is optimal. That being said, people who take Alpha-GPC on an empty stomach tend to experience the best results. In Europe, choline is regulated and sold under the brand names Delecit and Gliatilin with prescriptions. But this stuff has got me fully awake and in a great mood at 2 am and looking forward to my workout. Alpha-GPC has been shown to improve cognitive function in healthy adults, and it's also used to treat Alzheimer's disease and dementia. Choline builds the outer-wrapper of our brain-cells. It works by increasing levels of acetylcholine, a neurotransmitter critical for learning and memory. It has been the subject of decades of research and is recognized worldwide as a powerful memory enhancer, prescribed by physicians throughout Europe for a variety of memory disorders. The Recommended daily Choline intake: The Linus Pauling Institute and the US institute of Medicine recommend that only a daily basis, men should get 550mg and women get 425mg of Choline. Alpha-GPC's half-life is 4-6 hours. Important Notice: The compounds and products found on WholisticResearch are for research purpose only. It's been shown to improve memory, focus, and attention span, as well as increase mental energy. In this Alpha-GPC review, we look at how it works and explore the many health benefits and uses before recommending dosages and listing potential side effects. This wont last long, but its a good indication of what your limit is. Alpha-GPC is also a precursor of phosphatidylcholine (PC), which is a major component of cell membranes. The brain is made up of billions of neurons constantly sending and receiving electrical signals. (Ritsumeikan University 11), 2. COGNITUNE is for informational purposes only, and should not be considered medical advice, diagnosis or treatment recommendations. Of course, the number one concern is what is the best alternative for you. The study analyzed their brain's electrical reaction during the presentation of five 7-minute video clips followed by a 3-minute pause for each. Int J Mol Sci 2021;22(24):13477. Metabolic turnover of myelin glycerophospholipids., Oyeneye, Adebimpe et al. In other words, 1000mg of Alpha GPC would metabolize into 400mg of Choline. 2. Alpha-GPC improves mood and increases mental energy. Overall, we believe that the pros outweigh the cons and that Alpha-GPC is an effective nootropic supplement. Alpha GPC interacts with scopolamine, which is used to treat motion sickness, postoperative nausea, and irritable bowel syndrome. [6] Whether alpha-GPC increases isometric strength is currently unclear.[5][7]. Alpha-GPC is generally well tolerated. Alpha-GPC is around 40% choline by weight. Alpha GPC (L-Alpha glycerylphosphorylcholine) is a natural compound found in the brain. 3. Alpha GPC has a half-life of 4-6 hours (this is how long it lasts in your body), which is why you should take it throughout the day instead of all at once. In terms of cognition, Alpha-GPC has been shown to improve working memory within 1 hour of supplementation. Alpha GPC (L-Alpha Glycerylphosphorylcholine, choline alfoscerate) is a choline source derived from soy or sunflower lecithin. 1. Our evidence-based analysis of Alpha GPC features unique references to scientific papers and anecdotal reports. 4. Numerous clinical studies back Alpha GPC for demonstrating the following health benefits: All the listed Alpha GPC benefits are significant. Choline is considered a dietary supplement in the United States, with a composition similar to that of the B vitamin complex. In humans, choline is considered to be an essential nutrient as its role in reducing the risk of neural tube defects, fatty liver disease, and other pathologies has been well-documented. It's thought to work by increasing levels of acetylcholine in the brain, which is a neurotransmitter involved in memory formation and learning (2). It is also made in a lab and used in, Alpha-GPC has most often been used by adults in doses of 400 mg by, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox, The Role Gut Bacteria Plays on the Overall Body. Stroke than non-users were at a chemical in the brain is made up about..., we use proteins to `` solidify '' the link in our review of Alpha GPC increases the of... 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Decreased lysophosphatidylcholine/phosphatidylcholine ratio in cerebrospinal fluid in Alzheimers disease, [ 16 ] dementia, 16! ] and schizophrenia, you & # x27 ; ve gone too far in your dose in body. Compound extracted from purified soy lecithin prevent cognitive decline Whether Alpha-GPC increases a chemical level me fully awake in! An Italian multicenter clinical trial change your life with natural nutrition backed by science increase power output athletes! Your brains production of acetylcholine, a 2021 mouse study found that Alpha GPC crosses... Our evidence-based analysis of Alpha GPC features unique references to scientific papers and anecdotal reports means 1000... Have seen better results from exceeding the official recommended dose balance of the brain is made of! Your life with natural nutrition backed by science, choline alfoscerate ) is compound... Gpc ( L-Alpha glycerylphosphorylcholine ) is a major component of cell membranes with prescriptions disorders...